Stathmin 4
WebApr 11, 2024 · Stathmin 1 acts as a microtubule destabilizer by interacting with αβ-tubulin heterodimers and inhibiting microtubule polymerization. Stathmin 1 has two functional domains: The N-terminus domain facilitates microtubule depolymerization, and the C-terminus domain is indispensable for tubulin dimer binding and sequestering [ 12 ]. WebJan 18, 2024 · This study established the critical role of TDP-43 in RNA processing within motor neurons and showed that known ALS-associated mutations in TDP-43 dysregulate hundreds of its RNA targets, including stathmin-2. Specifically, TDP-43 depletion in the nucleus leads to aberrant splicing and premature polyadenylation of stathmin-2.
Stathmin 4
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WebHere, we design and characterize new stathmin-like domain (SLD) proteins that sequester tubulins in numbers different from two, the number of tubulins bound by stathmin or by the SLD of RB3, two stathmin family members that have been extensively studied. We established rules for the design of tight tubulin-SLD assemblies and applied them to ... WebStathmin has been investigated as a tumor biomarker because it appear to be associated with tumorigenesis; however, the effect of stathmin in lung adenocarcinoma (LAC) remains poorly understood.
WebMar 9, 2024 · 704.966.1650 4443 Henry Dellinger Road Suite E Maiden, NC 28650 WebFeb 19, 2024 · Stathmin expression is associated with aggressive tumour features Immunohistochemical staining of stathmin protein was mainly localised in the tumour cell cytoplasm, and was recorded as high in...
WebNov 14, 2024 · So far, four stathmins have been distinguished. All stathmins seem to interact with the tubulin network. STMN4 can be found within the Golgi apparatus, the … WebBoster Bio Anti-STMN4/Rb3 Antibody catalog # A13020. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100ul in Liquid form antibody.
WebNov 7, 2016 · Stathmin-like 4 is critical for the maintenance of neural progenitor cells in dorsal midbrain of zebrafish larvae. Meng-Ju Lin &. Shyh-Jye Lee. Scientific Reports 6, … latinx pronounce in spanishStathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene. Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell cytoskeleton. Changes in the cytoskeleton are important because the cytoskeleton is a scaffold required for … See more Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), a 78 amino acid coiled-coil region, and a short C-terminal domain. See more The function of Stathmin is to regulate the cytoskeleton of the cell. The cytoskeleton is made up of long hollow cylinders named microtubules. … See more Stathmin's role in regulation of the cell cycle causes it to be an oncoprotein named oncoprotein 18 (op18). Stathmin (aka op18) can cause … See more • Sobel A (August 1991). "Stathmin: a relay phosphoprotein for multiple signal transduction?". Trends in Biochemical Sciences. 16 (8): 301–5. doi:10.1016/0968-0004(91)90123-D See more Stathmin interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex. One mole of stathmin … See more Mice without stathmin have deficiency in innate and learned fear. Stathmin−/− females do not assess threats well, leading to lack of innate parental care and adult social interactions. They lack motivation for retrieving pups and are unable to choose a … See more • NLM • Stathmin.com See more latinx powerWebApr 6, 2024 · QRL-201 is a first-in-class therapeutic product candidate aiming to restore STATHMIN-2 (STMN2) expression in ALS patients. ANQUR is the first-ever study to evaluate a therapy that rescues STMN2 ... latinx professionalshttp://www.neobioscience.com/prod_view.aspx?TypeId=409&Id=2337947&FId=t3:409:3 latinx pronouncedWebStathmin-4Tubulin alpha-1B chainTubulin beta-2B chainTubulin-Tyrosine Ligase(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl ... latinx psychologyWebFeb 6, 2004 · Total Structure Weight: 219.72 kDa Atom Count: 14,074 Modelled Residue Count: 1,810 Deposited Residue Count: 1,934 Unique protein chains: 3 Display Files Download Files 1SA0 TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX PDB DOI: 10.2210/pdb1SA0/pdb Classification: CELL CYCLE Organism (s): Bos taurus, Rattus … latinx owned snack boxWebNov 27, 2013 · Fig. 4A shows that when the stathmin reduced the lateral bonding rate (k bond) by a factor of 2, the catastrophe rate of the simulated MTs increased almost … latinx psychology journal